Joseph Chaiken  Professor Interactions and processes relevant to laser chemistry and spectroscopy jchaiken@syr.edu phone: 315-443-4285 / fax: 315-443-4070 Office: CST 2-010 Education: • B.Sc., 1977, University of Chicago • Ph.D., 1982, University of Illinois at Urbana Courses: • CHE 116: General Chemistry • CHE 347: Physical - Analytical Chemistry Laboratory • CHE 356*: Physical Chemistry   * denotes current Spring '08 course

Research Interests Professor Chaiken's research interests are broad, although the underlying theme is to obtain a better understanding of the fundamental interactions and processes relevant to all kinds of laser chemistry and spectroscopy. In collaboration with Professor Jerry Goodisman at Syracuse, Chaiken has developed a model to describe coalescence growth. Coalescence growth systems are ubiquitous in nature and particularly important in laser chemical systems. They have successfully applied this model to data on cryogenic helium droplets in free jet expansions collected by Professor J. P. Toennies at the Max Planck Institute (Göttingen, Germany). In collaboration with his colleagues at the Air Force Research Laboratory, Chaiken uses lasers to manipulate the defect states in thin film tungsten oxide and related materials. Such chemistry is relevant to the design, fabrication, and function of nanoscale and microscale photonic devices. He also examines the use of lasers to noninvasively probe biological systems in vivo. His lab produced the first blood volume normalized noninvasive Raman spectrum of human blood in vivo. Shown below, the strength of the features in these spectra are proportional to the concentration of various analytes in the blood, including but not limited to glucose, total protein, albumin, cholesterol, urea, and triglycerides.
The first noninvasive Raman spectra of human blood in vivo was obtained by subtracting the spectrum (pressed) of a fingertip capillary bed depleted of blood by application of slight mechanical pressure, from another spectrum (unpressed) of the same capillary bed not depleted by slight mechanical pressure. The blood Raman spectra can be seen superimposed on top of the fluorescence from hemoglobin. The raw pressed (black-inset) and un-pressed (red-inset) and difference spectra, are not corrected for instrument response.	Tissue Modulated Spectrum being obtained from fingertip capillary bed
Selected Publications Chaiken, J.; Finney, W.F.; Knudson, P.E.; Weinstock, R.S.; Khan, M.; Bussjager, R.J.; Hagrman, D.; Hagrman, P.; Zhao, Y.; Peterson, C.M.; Peterson, K.P. The Effect of Hemoglobin Concentration Variation on the Accuracy and Precision of Glucose Analysis Using Tissue Modulated, Noninvasive, In Vivo Raman Spectroscopy of Human Blood: a Small Clinical Study. J. Biomed. Opt. 2005, 10(3), 31111. Chaiken, J.; Finney, W.F.; Yang, X.; Peterson, K.; Peterson, C.; Knudson, P.E.; Weinstock, R.S. Noninvasive, In-Vivo, Tissue Modulated Near Infrared Vibrational Spectroscopic Study of Human Blood: Microcirculation and Viscosity Effects. Proc. SPIE 2001, 4254, 106-118. Bussjager, R.; Osman, J.M.; Getbehead, M.; Capt Hinkel, D.; Grucza, D.; McEwen, T.; Myers, B.; Holtzhauer, N.; Chaiken, J. Spinning Disk Test Stand for Two-Color, Tungsten Oxide Based Optical Memory System. Jpn. J. Appl. Phys. 2001, 40, 789-796. Chaiken, J.; Finney, W.F.; Peterson, K.; Peterson, C.; Knudson, P.E.; Weinstock, R.S.; Lein, P. Noninvasive, In-Vivo, Tissue Modulated Near Infrared Vibrational Spectroscopic Study of Mobile and Static Tissues: Blood Chemistry. Proc. SPIE 2000, 3918, 135-143. Bussijager, R.; Chaiken, J.; Getbehead, M.; Grucza, D.; Capt. Hinkel, D.; McEwen, T.; Osman, J.; Voss, E. Using Tungsten Oxide Based Thin Films for Optical Memory and the Effects of Using IR Combined with Blue/Blue-Green Wavelengths. Jpn. J. Appl. Phys. 2000, 39, 789-796. » View all Publications